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KMID : 0381319930320020040
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Korean Journal of Occupational Health
1993 Volume.32 No. 2 p.40 ~ p.64
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Immunologic and Pathologic Changes to Some Drugs in the Experimental Pneumoconiosis
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윤임중/Yun, Im Goung
임영/노영만/김경아/임현우/오상용/정장영/Lim, Young/Roh, Young Man/Kim, Kyoung Ah/Lim, Hyun Woo/Oh, Sang Young/Jung, Chang Young
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Abstract
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To access the effects of some drugs such as piperazine phosphate, aspirin, azathioprine and allopurinol in the experimental pneumoconiosis, 263 rats weighted 240-320 gm was divided into the control and eight experimental groups.
To each group, the turbid solution mixed with free silica, talc and natural coal dust of 50 mg in 0.8 ml saline were instilled intratracheally.
At the begining and 5th week of experiment, piperazine phosphate (8mg/week orally). aspirin (1.5mg/day intramuscularly), azathioprine (25mg/day orally) and allopurinol (1.5mg/day orally) were administered simultaneously, while the dust turbid solution was only given to the control group. For each group the change of body weight, dry right lung weight, cellularity including total cell, macrophage, lymphocyte and neutrophil in bronchoalveolar lavage fluid, superoxide ion, hydroxyproline, leukotriene B4, tumor necrotsis factor, prostaglandin E., were examined, and observed the pathological chages in lung tissue.
The results were as follows :
1. The larger amount of their instilled dust and the longer observation period, the severer pathological findings were found in the lung tissue of each experimental group.
2. The body and dry right lung wight was not significantly changed in the experimental groups compared with the control group.
3. The number of total cell in bronchoalveolar lavage fluid was markedly less in the experimental group than the control one, while no significant difference was found in the percent of alveolar macrophages and lymphocytes in both groups. However, the percent of neutrophiles was usually lower than in the control group.
4. The amount of superoxide ion was frequently less in the experimental group compared with the control one.
5. the amount of hydroxyproline was significantly lower in tl.e experimental group than in the control one
6. The amount of leukotriene B4 was usually less in the drug administered group than in the control one.
7. The amount of tumor necrotic factor was also frequently lower in each experimental group than in the control one.
8. The amount of prostaglandin E2 was usually higher in each experimental group than r; in the control one.
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